New Advances in Mid-Infrared Photothermal Imaging

Video-rate mid-infrared photothermal imaging bysingle-pulse photothermal detection per pixel

Researchers from Boston University have unveiled a groundbreaking mid-infrared photothermal (MIP) imaging system capable of video-rate imaging by detecting single-pulse photothermal signals per pixel. This innovative system, achieved with the help of our 532 nm Cobolt Samba laser, significantly enhances imaging speed and sensitivity, making it possible to capture dynamic biological processes in real-time.

The new MIP microscope increases imaging speed by three orders of magnitude, achieving a line rate of over 2 kilohertz. This allows for the observation of biomolecular dynamics in living organisms at multiple scales. The system also uses hyperspectral imaging to chemically dissect the ultrastructure of fungal cell walls and map fat storage in live organisms.

This breakthrough was published in the academic journal Science Advances and details how this imaging technology can provide a powerful tool for high-throughput applications, enabling detailed and rapid analysis of biological systems without compromising sensitivity or resolution. The ability to capture fast lipid dynamics and other cellular activities in real-time opens up new possibilities for research in various scientific fields.