New Insights into Cadherin-Mediated Cell Adhesion

Cadherin clusters stabilized by a combination of specific and nonspecific cis-interactions

Researchers from the University of Colorado Boulder, the Albert Einstein College of Medicine and the University of Illinois Urbana-Campaign, have collaborated to unveil  the intricate mechanisms behind how cells stick together. The study focuses on cadherin proteins, which act like glue, helping cells adhere to one another.

Using advanced techniques, including dynamic single-molecule Förster Resonance Energy Transfer (FRET) and kinetic Monte Carlo (kMC) simulations, the researchers discovered that both specific and nonspecific interactions play a role in stabilizing cadherin clusters. These clusters are essential for strong cell-cell adhesion.

The group used our 532 nm DPSS Cobolt Samba laser at 50 mW for the fluorescence imaging, thus providing valuable insights into the molecular dynamics of cadherin proteins and enhancing our understanding of cellular adhesion.

This research marks a significant step forward in cell biology, offering a deeper understanding of how our bodies maintain their structural integrity at the cellular level.