Cobolt Blues and Jive in Uncoventional Protein Secretion

How proteins that cannot enter the ER–Golgi pathway of secretion are released into the extracellular space remains a fascinating question. A new study published in the Journal of Cell Biology sheds light on how these “unconventional” proteins find their way out. Researchers from the Barcelona Institute of Science and Technology, the University of Pompeu Fabra and the Riken Center for Advanced Photonics have identified a specialized compartment called CUPS (Compartment for Unconventional Protein Secretion) that forms independently of the traditional COPI and COPII vesicle systems (the cell pathway system).

The research group used Super-resolution confocal live imaging microscopy (SCLIM) and for the excitation of GFP and
Cherry, they used our solid-state lasers  Cobolt Blues emitting at 473 nm (50 mW) and the Cobolt Jive emitting at 561 nm (50 mW).

This study redefines our understanding of cellular logistics. By uncovering the mechanics of unconventional protein secretion, it highlights the cell’s remarkable adaptability and offers exciting possibilities for biomedical innovation.